Search Results for: attach
What is the address or URL to type when attaching to World Community Grid via BOINC?
Use http://www.worldcommunitygrid.org to attach to World Community Grid via BOINC.
How do I install the Linux application on Ubuntu or other Debian-based distributions?
In order to install the Linux application on Debian-based Linux distribution such as Ubuntu Linux, you will need to run the following commands:
sudo apt-get update
sudo apt-get install boinc-client boinc-manager
The application will be configured to automatically run when you restart your computer.
You will also need to attach your application to World Community Grid by running the following command:
sudo -u boinc boinccmd --project_attach http://www.worldcommunitygrid.org <Account Key>
Your <Account Key> can be found on your My Profile page.
What is the BOINC Client?
The BOINC client is a command line application that runs on Linux. This application contains the functions necessary to connect your Linux computer to World Community Grid. These functions include the following:
- Attach your computer to World Community Grid (use: http://www.worldcommunitygrid.org)
- Download work from the World Community Grid servers
- Return completed results to the World Community Grid servers
- Run the science application according to the preferences of the member
Why do I have a message that says my Account Key is missing?
When you installed our application, the Account Key was not properly assigned. Please take the following action:
- double left click on the World Community Grid or BOINC icon in your system tray
- click on "advanced view" (if not already in advanced view)
- click on your "projects" tab
- click on World Community Grid and then on the left hand menu select "detach"
- now, go to menu's at the top of your screen and select Tools -> Attach to Project
- this will bring up a panel that asks you to enter in a project URL. Please use: http://www.worldcommunitygrid.org
What is Ebola?
The Ebola virus, first identified in 1976 and named after the Ebola river near its outbreak, is a member of the filovirus family. The virus, which is shaped like a long, flexible filament, attaches to and drives itself into the cell. It then replicates efficiently, budding out numerous copies of itself from the cell. The virus attacks several types of cells, including important cells of the immune system that circulate and carry the virus throughout the body. The damage includes inappropriate clotting, leakage from blood vessels, inflammation, organ failure and shock. When a person is first infected, there is a two to 21 day incubation period before the infected person shows symptoms. Initial symptoms can closely resemble those caused by flu or common tropical diseases and progress to include high fever, vomiting, diarrhea, dehydration and more. Contact with an infected person's fluids or the body of a patient that died from disease can infect the next person.
I want to contribute to one of World Community Grid's research projects. How do I register for a particular research project and start contributing?
Members only need to register and attach once to World Community Grid in order to contribute to any, or all, of our research projects. In order to contribute, please take the following steps:
- Register with World Community Grid
- Select which of our research projects you wish to contribute to:
- The registration process gives you a list of research projects to choose from
- If you are already registered, you may change which projects you contribute to on your My Projects page
- If you do not already have BOINC installed, download and install the software
- If you already have the current version of BOINC installed, then you may participate in World Community Grid using your existing BOINC software. Just attach to World Community Grid using the URL: http://www.worldcommunitygrid.org and the email address and password you used at registration.
How does understanding protein structure help scientists understand the role of bacteria in human health?
Different proteins can have many different structures (shapes). They can have sticky portions which like to attach to certain chemical compounds, or repel them. They can sometimes be flexible. For example, enzymes are proteins which can enhance certain chemical reactions or even cut proteins or other compounds apart. Their structures and the patterns of electrical charges on their surface determine which other compounds they may interact with and how they may alter the other compounds.
Since cells use proteins for most of their basic life processes, their functions, determined by their structure, are very important. If these functions are disturbed, diseases can result. Since the human microbiome has over 1,000 times more different kinds of proteins than the human body, many of those have the potential for affecting human cells' operations. Some of these proteins can be beneficial or even necessary, while others may be harmful. This is an area which still needs a lot of exploration. One of the early steps in understanding the role of the microbiome is to discover the functions of its proteins. That requires discovering the structure of those proteins.
How do I install the Linux application on Red Hat or other Fedora-based distributions?
In order to install the Linux application on Fedora-based Linux distributions such as Red Hat Linux, you will first need to enable the Extra Packages for Enterprise Linux repository.
Further information and instructions about this process are available on the Fedora website's page for the Extra Packages for Enterprise Linux. For example, if you are enabling the EPEL repository for x86_64 Red Hat Enterprise Linux 6, you would run the following command:
sudo rpm -Uvh http://download.fedoraproject.org/pub/epel/6/x86_64/epel-release-6-8.noarch.rpm
Once the EPEL is enabled, install the Linux application by running:
sudo yum install boinc-client boinc-manager
To configure the application to automatically run when you restart your computer, please run the following command:
sudo /sbin/chkconfig boinc-client on
In order to start your application now, please run the following commands:
sudo /sbin/service boinc-client start
cd /var/lib/boinc
sudo -u boinc boinccmd --project_attach http://www.worldcommunitygrid.org <Account Key>
Your <Account Key> can be found on your My Profile page.
How does the GO Fight Against Malaria software work?
The GO Fight Against Malaria project uses software that automatically downloads small amounts of input data and then performs calculations that model how well different drug candidates interact with various molecular targets from the malaria parasite. After your device finishes one set of calculations, the results are sent by World Community Grid to a computer at The Scripps Research Institute. The Scripps research team then analyzes the results produced by all of the different donor machines on World Community Grid.
This project uses AutoDock 4.2 and the new AutoDock Vina computer software to evaluate how well each candidate compound (molecule) attaches ("docks" or "binds") against a malarial target (usually a protein molecule.) Millions of candidate compounds will be tested against 14 different molecular drug targets from the malaria parasite in order to discover new compounds that can block (inhibit) the activity of these multi-drug-resistant mutant superbugs. These candidates will be tested by docking flexible models of them against 3-D, atomic-scale models of different protein drug targets from the malaria parasite, to predict (a) how tightly these compounds might be able to bind, (b) where these compounds prefer to bind on the molecular target, and (c) what specific interactions are formed between the candidate and the drug target. In other words, these calculations will be used to predict the affinity/potency of the compound, the location where it binds on the protein molecule, and the mode it uses to potentially disable the target. Compounds that can bind tightly to the right regions of particular proteins from the malaria parasite have the potential to “gum up” the parasite’s machinery and, thus, help advance the discovery of new types of drugs to cure malaria.