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Human Proteome Folding Project Results |
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This page is a place holder for all of the known results from Phase 1 of the Human Proteome Folding project (HPF1). Only information provided to the World Community Grid team by the Human Proteome Folding research team is posted on this page.
HPF1 ran on World Community Grid from November 2004 through July of 2006. For more HPF1 information, click on the Original Description link on the left.
World Community Grid looks forward to providing additional results information about this project to you. As information becomes available, it will be added to the list below.
Added on March 29, 2007:
Public Library of Science (PLoS) publishes HPF1 paper in PLoS Biology Journal. The paper is entitled "Superfamily Assignments for the Yeast Proteome through Integration of Structure Prediction with the Gene Ontology".
Link to article:
http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0050076
Summary of Paper:
This paper shows that the computational power of World Community Grid running Rosetta along with described pre- and post-processing procedures can be used to increase the knowledge about protein structure for a whole genome. Yeast was used for this initial benchmark because it is so extensively studied and thus many of the results could be verified against prior work. Even so, many new protein structure predictions for yeast were found and classified. This information is now available in a data base provided by the researchers. Now that this technique has been demonstrated to have good value, the remaining proteins processed in the Human Proteome Project will go through these procedures creating a valuable resource for biologists studying cell processes and diseases. The results for these remaining processed genomes will be the subject of a subsequent paper and an even larger data base.
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World Community Grid's Advisory Board is looking for new research projects that can benefit from grid technology and have a positive impact on humanity.
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If you need technical assistance beyond what's available in Help, please visit the forums to post your questions and get answers on how others are using World Community Grid.
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