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The FightAIDS@Home Project in the Olson Laboratory is the computational component of a larger project at TSRI funded by the National Institute of Health, and led by Dr. Olson. Researchers participating in the FightAids@Home Project are:
Arthur J. Olson, Ph.D. Professor, Department of Molecular Biology, TSRI
David S. Goodsell, Ph.D. Associate Professor, Department of Molecular Biology, TSRI
Rik Belew, Ph.D. Professor and Chairman of Cognitive Science, UCSD
Garrett M. Morris, D. Phil., Staff Scientist, Department of Molecular Biology, TSRI
William Lindstrom, Ph.D. Postdoctoral Research Fellow, Department of Molecular Biology , TSRI
Alexandre Gillet, Computer System Administrator
Max Chang, Bioinformatics Graduate Student (with R. Belew), UCSD
Other laboratories within the project utilize the information generated by the computations in selecting, synthesizing, characterizing and testing new inhibitor molecules against HIV. These collaborating laboratories are:
The Elder Laboratory - Virology and Molecular Biology. The Elder laboratory produces mutational variants of the HIV Protease and develops and tests candidate inhibitors in vitro (ie. In the test tube).
The Sharpless Laboratory - Synthetic Chemistry. The Sharpless Laboratory (Prof. Barry Sharpless won the Nobel Prize in Chemistry in 2001) designs strategies for synthesizing libraries of chemical compounds to test as potential inhibitors of HIV protease.
The Stout Laboratory - Xray Crystallography. The Stout Laboratory experimentally determines the detailed atomic structures of HIV protease mutations and complexes of these structures with inhibitors.
The Torbett Laboratory - The Torbet Laboratory develops cell-based systems for producing HIV proteins and for testing the effects of potential inhibitors on the virus in living cells.
The Wlodawer Laboratory - Xray Crystallography. Crystallography The Wlodawer is a pioneer in the structural biology of HIV. They experimentally determine the structures of HIV protease in complex with promising inhibitors.
The Wong Laboratory - Synthetic Chemistry. The Wong Laboratory designs and synthesizes chemical inhibitors of HIV protease and other viral pathogens.
Below is a diagram of the interactions within the TSRI HIV Program Project.
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