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18 Mar 2025 – Research Update from the MCM Team (March 2025) |
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As part of our ongoing research updates, we continue to explore the top-scoring genes linked to lung cancer identified by the Mapping Cancer Markers (MCM) project. Following our previous focus on GCM1, this update examines DYNLT1 (Dynein Light Chain Tctex-Type 1), a gene with pivotal roles in intracellular transport and cancer pathophysiology. |
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Project Update
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21 Jan 2025 – Research Update from the MCM Team (January 2025) |
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We continue to investigate molecular signatures linked to lung cancer, with a current focus on GCM1, a transcription factor involved in placental development and potentially significant in lung cancer biology. The GCM1 gene encodes a protein with a gcm-motif, playing a central role in DNA-binding and regulating placental-specific genes. While its primary function is in placental biology, emerging evidence suggests GCM1 mutations are implicated in various cancers, including lung adenocarcinoma (ADC). |
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Project Update
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26 Nov 2024 – Two projects come to an end |
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Smash Childhood Cancer and Help Stop TB concluded their phase with the WCG and are providing us with a final update. |
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Project Update
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31 Oct 2024 – ARP restart update |
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The ARP project will be restarting by Monday November 4, following the technical pause it entered in December 2022. |
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Project Update
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10 Jul 2024 – Research Update from the MCM team (July 2024) |
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We continue to characterise lung cancer biomarkers identified in the MCM1 project. This update focuses on ASTN2, a protein involved in neuronal migration. It is expressed across several tissue types, and has been implicated in various cancers. |
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Project Update
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13 May 2024 – Research update from the MCM team (May 2024) |
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We continue to characterise lung cancer biomarkers identified in the MCM1 project. This update focuses on KLF5, a well-studied gene that has been implicated in several cancer types. KLF5 is a transcription factor, which is expressed across numerous organs and tissues. |
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Project Update
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25 Apr 2024 – ARP restart update |
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The ARP team is preparing to restart after the project was put on pause in December 2022. This article outlines the steps that we are taking in order to restart this project. |
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Project Update
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14 Mar 2024 – Research update from the MCM team (March 2024) |
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We continue to characterise lung cancer biomarkers identified in the MCM1 project. This update focuses on HSD17B11, a gene associated with lung cancer survival. HSD17B11 is a protein coding gene, relatively ubiquitously expressed across organs and tissues. It is a short-chain alcohol dehydrogenase that metabolises secondary alcohols and ketones. |
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Project Update
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