Dr. Alessandra Carbone, the primary investigator for the Help Cure Muscular Dystrophy project, recently published a paper along with several colleagues to propose new techniques for looking at the complexities of protein-protein interactions.
Unlocking the mysteries of protein-protein interactions will lead to a greater understanding of many biological processes, and could help scientists better address human health and disease. However, predicting and visualizing all possible protein interactions is highly complex and challenging. Some protein surfaces are involved in many interactions with other proteins, while others are not. Predicting the nature of these protein surfaces continues to be a challenge.
To help address this complexity, Dr. Alessandra Carbone and her colleagues, Dr. Chloé Dequeker and Dr. Elodie Laine, conducted a study which made use of Help Cure Muscular Dystrophy results from World Community Grid. The study combines different types of information to predict protein surfaces which interact with other proteins and disentangles the complexity of the interacting surfaces. Their results were recently published in Proteins: Structure, Function, and Bioinformatics.
This open-access paper includes details of their findings, as well as links to their data and software. You can read the full paper here.
Thank you to all the volunteers who helped make this study possible by supporting the Help Cure Muscular Dystrophy project.