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January/February Update: Smash Childhood Cancer
23 Feb 2021   

Summary

Lab testing has begun for several drug candidates that may target proteins that play a role in certain childhood cancers.


Background

The Smash Childhood Cancer research team has identified proteins and other molecules that play key roles in certain childhood cancers. The challenge is now to find chemical drug candidates that specifically target these key molecules and therefore control the cancer cells.

Deciding on the project's next target

The research team has a list of additional potential targets that may be significant in the development of various childhood cancers. They are now conducting a review on the existing literature about these targets. This is a first step to narrow down the original list, and to help the researchers decide what to focus on next.

Data analysis

The research team continues to analyze data from the previous batches of work run on World Community Grid.

Below are the key proteins that have been examined so far and for which we have new updates. Each protein listed is involved in the development of at least one type of childhood cancer.


Beta catenin    
Late last year, the researchers identified a compound that may be effective at targeting this protein. This compound is now undergoing testing.*

Osteopontin
Testing has now begun on several compounds that may be effective at targeting this protein.*

PAX3:FOX01  
Late last year, the researchers identified a compound that may be effective in targeting this protein, and lab testing has now begun for the compound.*


*Lab testing compounds for effectiveness generally requires several phases, and each phase can take at least several months.

Current status of work units

Project paused

 

Click here to learn more about World Community Grid's monthly project updates.

 

 




Research Call Notes