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April Update: Smash Childhood Cancer
29 Apr 2021   

Summary

The researchers are deep into early analysis for several key proteins that are significant in the development of certain childhood cancers.


Background

The Smash Childhood Cancer research team has identified proteins and other molecules that play key roles in certain childhood cancers. The challenge is now to find chemical drug candidates that specifically target these key molecules and therefore control the cancer cells.

Continuing data analysis

Since early this year, the researchers have been analyzing data from work run on World Community Grid.

Below are the key proteins for which we have new updates. Each of these proteins is involved in the development of at least one type of childhood cancer.


Osteopontin
The researchers' initial findings for several compounds that may target this protein are promising. The lab that is handling the testing will be working with a biochemist to conduct further research.*

PRDM14
The researchers have list of more than a dozen compounds that they want to test against this protein. They are going through the purchasing process, and are also working on getting help from a medicinal chemist for this testing.*

TrkB (NTRK2)
The researchers are working to obtain funding to study this protein further.


*Lab testing compounds for effectiveness generally requires several phases, and each phase can take at least several months.

Current status of work units

Paused

 

Click here to learn more about World Community Grid's monthly project updates.




Research Call Notes