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July Update: Smash Childhood Cancer
20 Jul 2021   

Summary

The researchers continue to do lab testing based on data from their most recent work on World Community Grid.


Background

The Smash Childhood Cancer research team has identified proteins and other molecules that play key roles in certain childhood cancers. The challenge is now to find chemical drug candidates that specifically target these key molecules and therefore control the cancer cells.

Data analysis updates

Since early this year, the researchers have been analyzing data from work run on World Community Grid.

Below are the key proteins for which we have new updates this month. Each of these proteins is involved in the development of at least one type of childhood cancer.


Beta catenin
Early testing on the three compounds mentioned earlier this year is promising, particularly for two of the compounds. The researchers have begun writing about their findings. They are also considering bringing in additional collaborators to help with further testing of the compounds.

Osteopontin
A biochemist collaborator is beginning further testing on this key protein.

PRDM14
The researchers have tested 11 compounds to see if and how they might target this protein. One shows promise so far, and will be tested further.


Note: Lab testing compounds for effectiveness generally requires several phases, and each phase can take at least several months.

Current status of work units

Paused

 

Click here to learn more about World Community Grid's monthly project updates.




Research Call Notes