Connecting to the Server

What ports do I have to open on my firewall to let the software connect to the server?

Open ports 80, 443 and 31416 outbound.

What should I do if I receive a pop-up from an Anti-spy programs and/or pop-up blockers

There are normally no pop-ups to block. Any anti-spy program which acts like an outgoing firewall would have to be configured in a manner similar to the fiewall settings

How will World Community Grid software affect people who use a VPN for telecommuting?

The software will not have any effect. The software communicates without problems with, or without, VPN Client Software. Our server site is an external internet address. The bandwidth usage is minimal and equivalent to visiting a few web pages once a week or every few days on more powerful computers.