Log In Join Now
Forums  |  Help  |  Settings  |  Download
Help: Topic
 
Getting Started
Overview
Website
Forums
Project Progress
Project Updates
API
What is World Community Grid?
Costs
Social Networking
FightAIDS@Home - Phase 2
Project information
Scientific background
Project graphics
Outsmart Ebola Together
Project information
Scientific background
Project graphics
Uncovering Genome Mysteries
Project information
Scientific background
Project graphics
Mapping Cancer Markers
Project information
Scientific background
Project graphics
Computing for Sustainable Water
Say No to Schistosoma
GO Fight Against Malaria
Drug Search for Leishmaniasis
Computing for Clean Water
The Clean Energy Project - Phase 2
Discovering Dengue Drugs - Together - Phase 2
Help Cure Muscular Dystrophy - Phase 2
Influenza Antiviral Drug Search
Help Fight Childhood Cancer
The Clean Energy Project
Nutritious Rice for the World
Help Conquer Cancer
AfricanClimate@Home
Discovering Dengue Drugs - Together
Help Cure Muscular Dystrophy
Genome Comparison
Help Defeat Cancer
FightAIDS@Home
Human Proteome Folding
Human Proteome Folding - Phase 2
Points
Returning Results
Teams
Team Challenges
Help Stop TB
Project information
Scientific background
Project graphics
OpenZika
Project information
Scientific background
Project graphics
Smash Childhood Cancer
Project information
Project graphics
Microbiome Immunity Project
Project information
Scientific and technical background
Project graphics
Africa Rainfall Project
OpenPandemics - COVID-19
Project Information
Scientific and Technical Background
Project Graphics
Troubleshooting
Search for help about: Go
 

Scientific and Technical Background


What is COVID-19?

Coronavirus disease 2019 (COVID-19) is a disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) a virus that belongs to the coronavirus family, which includes also SARS-CoV (responsible of the SARS outbreak of 2003) and the MERS-CoV (responsible of the MERS outbreak of 2013). These viruses share the common trait of infecting the human respiratory system and can cause serious illness or even death. First identified as a pneumonia of unknown origin at the end of 2019, the disease was named COVID-19 in February 2020. COVID-19 proved to be highly infectious and quickly spread to every continent.

Return to Top 

Why is COVID-19 considered to be so dangerous?

COVID-19 is considered to be highly infectious disease, since the virus is usually spread through droplets generated when an infected person coughs or sneezes, or through droplets of saliva or discharge from the nose. The World Health Organization has stated that COVID-19 may be able to spread in all types of weather and may not necessarily require direct contact with an infected person. The virus can affect people of all ages, although the elderly, immunocompromised, and anyone with existing health problems are believed to be more susceptible.

As of the launch of this project, there is no effective treatment, cure, or vaccine for COVID-19.

Return to Top 

There are other volunteer computing projects related to COVID-19? Does the world really need more than one?

Yes! There other volunteer computing projects right now that are part of the fight against COVID-19, and they are all doing important work. Understanding the molecular structure of the virus that causes COVID-19, searching for treatments, and ultimately finding a vaccine, requires an "all hands on deck" approach from scientists, government agencies, businesses, and the general public.

Return to Top 

How exactly does this project use computing power to look for potential COVID-19 treatments?

The Forli Lab is using a process known as molecular docking, which is the study of how two or more molecules fit together, such as a protein in a human cell or in a virus, and a chemical compound. In OpenPandemics - COVID-19, the researchers are leveraging this technique at scale, thanks to World Community Grid's massive computational power, by virtually screening millions of chemical compounds to see which might be capable of binding to proteins of the SARS-Cov2, as well as other coronaviruses proteins. This helps them identify which compounds could be effective against the virus and therefore may be able to contrast the COVID-19 progression. Promising compounds will then proceed through the drug discovery process, which includes laboratory testing and chemical optimizations.

The researchers plan to screen compounds from various sources including existing commercially available and clinically tested compounds, focused libraries generated in silico, as well as in-house libraries of compounds that are available at Scripps Research.

Return to Top 

Where can I learn more about COVID-19, SARS-CoV2, and other coronaviruses?

The Center for Disease Control and World Health Organization have many resources that are continually updated with the newest information about COVID-19.

Members of the Center for Computational Structural Biology at Scripps Research are also producing materials about SARS-CoV-2 (the virus that causes COVID-19) and its molecules, including accurate 3D models, illustrations and educational materials, including CellPAINT, a program that allows you to draw your own pictures of the virus.

Return to Top 

What are the system requirements for devices to participate in OpenPandemics – COVID-19?

Any laptop or desktop can be used. OpenPandemics – COVID-19 runs on Windows, Mac, and Linux systems. Learn more about the system requirements at https://www.worldcommunitygrid.org/help/viewTopic.do?shortName=minimumreq

Return to Top