Log In Join Now
Forums  |  Help  |  Settings  |  Download
 
Human Proteome Folding Project Results

This page is a place holder for all of the known results from Phase 1 of the Human Proteome Folding project (HPF1). Only information provided to the World Community Grid team by the Human Proteome Folding research team is posted on this page.

HPF1 ran on World Community Grid from November 2004 through July of 2006. For more HPF1 information, click on the Original Description link on the left.

World Community Grid looks forward to providing additional results information about this project to you. As information becomes available, it will be added to the list below.

Added on September 16, 2008:
Cell Press publishes HPF1 paper in Cell Journal. The paper is entitled "A Protein Domain-Based Interactome Network for C. elegans Early Embryogenesis".

Link to article:
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WSN-4T5BPWS-R&_user=30681&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_version=1&_urlVersion=0&_userid=30681&md5=96bdd6c1e59c885978a5c7500b569bd5

Click here to view a PDF file of the article

Summary of Paper:
The paper "A Protein Domain-Based Interactome Network for C. elegans Early Embryogenesis" in Cell, August 8, 2008 issue was made possible, partly due to the results of the Human Proteome Folding project on World Community Grid. The protein structure predictions computed using World Community Grid identified additional proteins involved in the orchestration of how a nematode embryo first develops. This enabled the authors to test a new method for discovering such orchestrations (called interactome networks) using a well understood species of nematode as a proof of concept. This should eventually lead to faster understanding of all kinds of biological processes, including disease processes and speed discoveries for treating and curing diseases.

Added on March 29, 2007:
Public Library of Science (PLoS) publishes HPF1 paper in PLoS Biology Journal. The paper is entitled "Superfamily Assignments for the Yeast Proteome through Integration of Structure Prediction with the Gene Ontology".

Link to article:
http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0050076

Summary of Paper:
This paper shows that the computational power of World Community Grid running Rosetta along with described pre- and post-processing procedures can be used to increase the knowledge about protein structure for a whole genome. Yeast was used for this initial benchmark because it is so extensively studied and thus many of the results could be verified against prior work. Even so, many new protein structure predictions for yeast were found and classified. This information is now available in a data base provided by the researchers. Now that this technique has been demonstrated to have good value, the remaining proteins processed in the Human Proteome Project will go through these procedures creating a valuable resource for biologists studying cell processes and diseases. The results for these remaining processed genomes will be the subject of a subsequent paper and an even larger data base.


Return to Top