The Scripps Research Institute
La Jolla, California, USA
The Scripps Research Institute (TSRI) is a nonprofit research institution whose philosophy emphasizes the creation of basic knowledge in the biosciences for its application in medicine and the pursuit of fundamental scientific advances. The more than 200 principal investigators at TSRI include many distinguished leaders in their fields, including two Nobel laureates and numerous members of the National Academy of Sciences (including its Institute of Medicine), American Academy of Arts and Sciences, and American Association for the Advancement of Science.
Arthur J. Olson
Arthur Olson is the Anderson Research Chair Professor at the Scripps Research Institute, where 35 years ago he founded and still directs the Molecular Graphics Laboratory. His lab has created both AutoDock and AutoDock Vina, the world's most widely used and cited molecular docking programs. Olson is the Director of the NIH-funded HIV Interaction and Viral Evolution (HIVE) Center. He initiated the volunteer computing HIV project, FightAIDS@Home, in 2000, which has run on IBM's World Community Grid since 2005.
Dr. Stefano Forli is a Staff Scientist in Prof. Olson's laboratory at TSRI, which he joined in 2008. He received his Ph.D in 2006 in Medicinal Chemistry at the Universita' degli Studi di Siena, Italy. His main expertise is in docking, high throughput virtual screening and structure-activity relationships. The main goal of his research is to exploit structural information for drug discovery to find novel molecules able to bind to and inhibit HIV proteins.
Dr. Pierrick Craveur joined Prof. Olson's laboratory in 2016 as a Research Associate. He received his Ph.D in 2014 in Computational Structural Biology at Paris Diderot University. He is an expert in protein structure, molecular modeling, and molecular dynamic simulation. His research is focused on protein structures and prediction of their flexibility to find interaction sites between drugs and HIV protein targets.
There are 14 laboratories in 8 institutions around the U.S. that collaborate on HIV research through the HIVE Center. The HIVE Center comprises a group of investigators with expertise in HIV crystallography, virology, molecular biology, biochemistry, synthetic chemistry and computational biology. We study the mechanistic implications of viral macromolecular interactions and dynamics and its broader impacts of the evolution of drug resistance to address several biological questions:
- How do structures of the HIV polyprotein precursors direct assembly, maturation, and replication?
- What novel HIV-Host interactions drive DNA replication and integration?
- How does dynamics impact viral function and fitness and how can it be exploited for therapeutic targeting?
- What are the structural and dynamic consequences of resistance mutations in the HIV life cycle?
For details of the research of each of these investigators, please visit: hivecenter.org
Ronald M. Levy
Ronald M. Levy is Laura H. Carnell Professor and Director of the Center for Biophysics and Computational Biology at Temple University, Philadelphia, PA. Before moving to Temple in 2014, he was Board of Governors Professor of Chemistry at Rutgers University. Levy is one of the founding members of the group of scientists who developed molecular dynamics simulations of proteins into the powerful technique used in biophysics and structural biology that it is today. Using computational statistical mechanics as a framework, he has been a leader in studying solvation effects in chemistry and biophysics, and in developing free energy methods and effective potentials for simulating protein-ligand binding. His group developed the Impact commercial software package used for many years by Schrodinger Inc. as an integral part of their docking suite, and the academic Impact package which performs protein-ligand binding free energy simulations using the BEDAM technology.
Associate Research Professor
Dr. Nanjie Deng is a Senior Scientist in Ron Levy's laboratory at Temple University. The main focus of his research is to use computer simulation and statistical mechanics to provide atomistic insights on protein-small molecule interaction and protein-protein association to inform structure based drug design, and to understand the molecular basis of drug resistance mutations in HIV targets.
Associate Research Professor
Dr. Junchao Xia is a Research Scientist at Ron Levy's group. He is one of the main developers for Academic IMPACT and porting it to World Community Grid. His major research interests are protein-ligand interactions and developments of advanced sampling methods for computer simulations.
William is a Graduate Student in the Department of Physics and Astronomy at Rutgers University studying under Ron Levy. His research is focused on developing models to understand the fitness of proteins, and the development and application of large-scale parallelized computations.