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18 Mar 2025 – Research Update from the MCM Team (March 2025) |
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As part of our ongoing research updates, we continue to explore the top-scoring genes linked to lung cancer identified by the Mapping Cancer Markers (MCM) project. Following our previous focus on GCM1, this update examines DYNLT1 (Dynein Light Chain Tctex-Type 1), a gene with pivotal roles in intracellular transport and cancer pathophysiology. |
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Project Update
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21 Jan 2025 – Research Update from the MCM Team (January 2025) |
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We continue to investigate molecular signatures linked to lung cancer, with a current focus on GCM1, a transcription factor involved in placental development and potentially significant in lung cancer biology. The GCM1 gene encodes a protein with a gcm-motif, playing a central role in DNA-binding and regulating placental-specific genes. While its primary function is in placental biology, emerging evidence suggests GCM1 mutations are implicated in various cancers, including lung adenocarcinoma (ADC). |
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Project Update
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10 Jul 2024 – Research Update from the MCM team (July 2024) |
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We continue to characterise lung cancer biomarkers identified in the MCM1 project. This update focuses on ASTN2, a protein involved in neuronal migration. It is expressed across several tissue types, and has been implicated in various cancers. |
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Project Update
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13 May 2024 – Research update from the MCM team (May 2024) |
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We continue to characterise lung cancer biomarkers identified in the MCM1 project. This update focuses on KLF5, a well-studied gene that has been implicated in several cancer types. KLF5 is a transcription factor, which is expressed across numerous organs and tissues. |
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Project Update
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14 Mar 2024 – Research update from the MCM team (March 2024) |
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We continue to characterise lung cancer biomarkers identified in the MCM1 project. This update focuses on HSD17B11, a gene associated with lung cancer survival. HSD17B11 is a protein coding gene, relatively ubiquitously expressed across organs and tissues. It is a short-chain alcohol dehydrogenase that metabolises secondary alcohols and ketones. |
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Project Update
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16 Jan 2024 – Research update from the MCM team (January 2024) |
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We continue our work on characterizing lung cancer biomarkers identified in the MCM1 project. This update focuses on PCSK5, a gene associated with lung cancer survival and which shows differential expression across various cancer types. |
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Project Update
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27 Nov 2023 – Research update from the MCM team (November 2023) |
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We continue our work on characterizing lung cancer biomarkers identified in the MCM1 project. This update focuses on IL13RA1, a gene associated with lung cancer survival and differentially expressed across multiple cancer types compared to normal tissues. |
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Project Update
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15 Sep 2023 – MCM team update: ADH6 |
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We continue our work on characterizing lung cancer biomarkers identified in the MCM1 project. This update focuses on ADH6, a gene associated with smoking status and lung cancer prognosis. |
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Project Update
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