The initial childhood cancers being addressed are: neuroblastoma (nerve cancer), brain tumors, Wilms' tumor (kidney tumor), germ cell tumors, hepatoblastoma (liver cancer), and osteosarcoma (bone cancer).
The project is focusing on these particular childhood cancers because the researchers have discovered target molecules related to these diseases. The molecular structures of these targets have already been determined through previous research, and scientists believe these targets can be used to control the cancer. The research team aims to find drug candidates which can disable or enhance the activity of these target molecules, in order to control or cure the cancer.
Some of these target molecules are also involved with a number of adult cancers (colorectal cancer, lung cancer, gastric cancer, pancreatic cancer, renal cancer, liver cancer, nasopharyngeal cancer, prostate cancer and others) and may therefore help with treatments for those diseases, too.